Description

tert-Butyl Azetidine-3-Carboxylate Hcl CAS NO 53871-08-2 is a high-purity, protected azetidine carboxylic acid derivative, serving as a critical chiral building block in advanced organic synthesis. Its primary value lies in enabling the efficient construction of complex nitrogen-containing heterocycles, which are central to modern drug discovery programs. This intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry for CNS and oncology targets.
• Protease Inhibitor Synthesis: Used in the construction of complex molecular scaffolds for protease inhibitor development.
• Peptidomimetic Chemistry: Serves as a constrained amino acid analog for designing and synthesizing peptidomimetics with enhanced metabolic stability.
• Agrochemical Research: Employed as a building block for developing new herbicides and pesticides with novel modes of action.
• Ligand and Catalyst Development: Useful in the preparation of chiral ligands and organocatalysts for asymmetric synthesis.
• Academic and R&D Laboratories: A valuable reagent for methodological studies in heterocyclic and synthetic organic chemistry.

Basic Information

Product Name	tert-Butyl Azetidine-3-Carboxylate Hcl
CAS No.	53871-08-2
Molecular Formula	C8H16ClNO2
Molecular Weight	193.67 g/mol
Synonyms	1-Boc-3-Azetidinecarboxylic Acid Hydrochloride; tert-Butyl 3-Carboxyazetidine-1-carboxylate Hydrochloride; 1-(tert-Butoxycarbonyl)azetidine-3-carboxylic Acid Hydrochloride; 3-Azetidinecarboxylic acid, 1-(1,1-dimethylethyl) ester, hydrochloride; Boc-Azetidine-3-COOH·HCl; Azetidine-3-carboxylic acid, N-Boc-protected, hydrochloride; 1-Boc-Azetidine-3-Carboxylic Acid HCl Salt
EINECS	Contact for details

Quality Control

Every batch of tert-Butyl Azetidine-3-Carboxylate Hcl is produced under strict quality management protocols. We ensure compliance with high-purity standards suitable for research and GMP-grade applications. Comprehensive analytical testing, including HPLC, NMR, and chiral purity analysis, is performed to guarantee identity, potency, and purity. A detailed Certificate of Analysis (COA) is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.