Description

Ethyl 3-Butynoate is a versatile alkyne-containing ester building block, essential for advanced organic synthesis. Its terminal alkyne functionality makes it a critical precursor for click chemistry, Sonogashira couplings, and the construction of complex molecular architectures. This high-purity intermediate is primarily sought by research and development laboratories, pharmaceutical companies, and fine chemical manufacturers for applications in drug discovery, material science, and agrochemical development.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and novel drug candidates via Huisgen cycloaddition and cross-coupling reactions.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and plant growth regulators that require alkyne motifs.
• Material Science & Polymer Chemistry: Serves as a monomer or cross-linking agent for creating specialty polymers, dendrimers, and functionalized surfaces.
• Click Chemistry Reagent: An ideal substrate for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions to create 1,2,3-triazoles.
• Organic Synthesis & Research: A fundamental reagent for Sonogashira, Glaser, and other palladium-catalyzed coupling reactions in academic and industrial R&D.
• Ligand & Catalyst Development: Used to synthesize complex chelating ligands and organometallic catalysts.

Basic Information

Product Name	Ethyl 3-Butynoate
CAS No.	53841-07-9
Molecular Formula	C6H8O2
Molecular Weight	112.13 g/mol
Synonyms	Ethyl But-3-ynoate; 3-Butynoic Acid Ethyl Ester; Ethyl Tetrolate; Ethyl Propiolacetate; Acetyleneacetic Acid Ethyl Ester; But-3-ynoic Acid Ethyl Ester; Ethyl 3-Butyn-1-oate
EINECS	Contact for details

Quality Control

Our Ethyl 3-Butynoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong acids and oxidizing agents. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Recommended storage temperature: 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index (20°C)	1.420 - 1.425
Density (20°C)	0.95 - 0.98 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.