Description

L-Glutamic Acid, 5-(1,1-Dimethylethyl) 1-Methyl Ester is a protected derivative of the essential amino acid L-glutamic acid, featuring a tert-butyl ester group at the 5-position and a methyl ester at the 1-position. This specific molecular architecture is critical for its role as a key synthetic intermediate and protecting group strategy in advanced organic synthesis. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and fine chemical sectors. The compound's defined structure enables precise chemical modifications while safeguarding reactive functional groups during multi-step synthetic sequences.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of complex peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce glutamic acid residues with orthogonal protecting groups.
• Biochemical Research: Employed in the study of enzyme substrates, receptor ligands, and metabolic pathways involving glutamatergic systems.
• Fine Chemical Synthesis: Acts as a chiral synthon for the preparation of non-proteinogenic amino acids and other specialty organic compounds.
• Agrochemical Development: Potential intermediate in the research and synthesis of novel herbicides, pesticides, or plant growth regulators with amino acid backbones.

Basic Information

Product Name	L-Glutamic Acid, 5-(1,1-Dimethylethyl) 1-Methyl Ester
CAS No.	53838-27-0
Molecular Formula	C10H19NO4
Molecular Weight	217.26 g/mol
Synonyms	L-Glutamic acid 5-tert-butyl 1-methyl ester; (S)-5-(tert-Butoxy)-4-methoxy-5-oxopentanoic acid; 1-Methyl 5-tert-butyl L-glutamate; Methyl N-tert-butoxycarbonyl-L-glutamate; Boc-Glu-OMe; Boc-L-Glutamic acid 1-methyl ester; L-Glutamic acid, 5-(1,1-dimethylethyl) methyl ester; Methyl Boc-L-glutamate
EINECS	Contact for details

Quality Control

Our production of L-Glutamic Acid, 5-(1,1-Dimethylethyl) 1-Methyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC and identity confirmation by IR and NMR spectroscopy. A detailed Certificate of Analysis (COA) documenting purity, specific rotation, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product may be hygroscopic; therefore, the container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Specific Rotation	[α]20/D: Contact for details
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.