Description

Benzyl 2,3,4-Tri-o-Benzyl-D-Glucuronate is a key protected intermediate in synthetic organic chemistry, specifically designed for the controlled introduction of the glucuronic acid moiety. This compound is critical for researchers and manufacturers requiring high-purity building blocks for complex carbohydrate and glycoconjugate synthesis. It is primarily utilized in pharmaceutical R&D for the production of advanced drug candidates, prodrugs, and diagnostic agents where precise glycosylation is essential.

Application

• Pharmaceutical Intermediate: A crucial protected precursor for synthesizing glucuronide prodrugs, which are designed for targeted drug delivery and enhanced bioavailability.
• Glycoconjugate Synthesis: Serves as a versatile building block for the preparation of complex oligosaccharides, glycoproteins, and glycolipids in medicinal chemistry.
• Biochemical Research: Used in enzymatic and chemical studies to investigate glucuronidation pathways, a major Phase II drug metabolism process.
• Standards & Reference Material: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Carbohydrate Chemistry: Essential for the stereoselective synthesis of D-glucuronic acid derivatives under protective group strategies.

Basic Information

Item	Details
Product Name	Benzyl 2,3,4-Tri-o-Benzyl-D-Glucuronate
CAS No.	53684-90-5
Molecular Formula	C34H34O7
Molecular Weight	554.63 g/mol
Synonyms	D-Glucuronic Acid, Benzyl Ester, 2,3,4-Tris-O-(phenylmethyl)-; Benzyl 2,3,4-Tri-O-benzyl-β-D-glucopyranosiduronate; 2,3,4-Tri-O-benzyl-D-glucuronic Acid Benzyl Ester; Benzyl (2,3,4-Tri-O-benzyl-β-D-glucopyranosyl)uronate; Glucuronic Acid Benzyl Ester Tri-Benzyl Ether; Benzyl 2,3,4-Tri-O-benzyl-1-thio-β-D-glucopyranosiduronate (related thio analog); Protected D-Glucuronate Benzyl Ester
EINECS	Contact for details

Quality Control

Every batch of Benzyl 2,3,4-Tri-o-Benzyl-D-Glucuronate is manufactured and tested under a strict quality management system. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed HPLC purity, identity confirmation (IR, NMR), and impurity profiles. Our quality protocols are designed to meet the exacting standards required for pharmaceutical R&D and fine chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and should be handled under an inert atmosphere when appropriate for prolonged stability.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.