Description

4-Isothiocyanatobenzoyl Chloride is a versatile and highly reactive bifunctional organic intermediate. Its core value proposition lies in its ability to act as a key building block for synthesizing more complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), diagnostic reagents, and specialized polymers. Its dual functionality allows for efficient conjugation and derivatization reactions, making it a critical material for advanced chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in oncology and diagnostic imaging agents.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, leveraging its reactive isothiocyanate and acid chloride groups.
• Bioconjugation Reagent: Facilitates the labeling and cross-linking of proteins, peptides, and other biomolecules for research and diagnostic applications.
• Polymer Chemistry: Serves as a monomer or cross-linking agent for creating specialty polymers with unique thermal or mechanical properties.
• Chemical Research: A valuable reagent in organic synthesis for constructing heterocyclic compounds and other complex molecular architectures.
• Material Science: Used in surface modification and the development of advanced functional materials.

Basic Information

Product Name	4-Isothiocyanatobenzoyl Chloride
CAS No.	53611-24-8
Molecular Formula	C8H4ClNOS
Molecular Weight	197.64 g/mol
Synonyms	p-Isothiocyanatobenzoyl Chloride; 4-Isothiocyanatobenzoyl Chloride; Benzoyl chloride, 4-isothiocyanato-; 1-Chloro-4-isothiocyanatobenzene-1-carbonyl; 4-(Isothiocyanato)benzoyl chloride; Isothiocyanic acid, 4-(chlorocarbonyl)phenyl ester
EINECS	Contact for details

Quality Control

Our 4-Isothiocyanatobenzoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.