Description

6-Amino-2-Chloronicotinonitrile is a versatile and high-value heterocyclic building block, specifically a substituted pyridine derivative. Its molecular structure, featuring both amino and chloro substituents on the nitrile-functionalized pyridine ring, makes it a critical intermediate for synthesizing complex molecules. This compound is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical sectors. It enables the construction of advanced scaffolds for active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of various drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging its pyridine core for bioactivity.
• Ligand and Catalyst Development: Serves as a starting material for creating novel ligands used in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized organic molecules for electronic materials and organic light-emitting diodes (OLEDs).
• Chemical Biology Probes: Utilized to build molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: A fundamental building block for custom chemical synthesis services catering to R&D and pilot-scale production.

Basic Information

Item	Details
Product Name	6-Amino-2-Chloronicotinonitrile
CAS No.	53554-20-4
Molecular Formula	C6H4ClN3
Molecular Weight	153.57 g/mol
Synonyms	2-Chloro-6-aminonicotinonitrile; 2-Chloro-6-aminopyridine-3-carbonitrile; 3-Cyano-2-chloro-6-aminopyridine; 6-Amino-2-chloro-3-cyanopyridine; 2-Chloro-3-cyano-6-aminopyridine; 6-Amino-2-chloropyridine-3-carbonitrile; 2-Chloro-6-amino-3-pyridinecarbonitrile
EINECS	Contact for details

Quality Control

Our 6-Amino-2-Chloronicotinonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity determination and NMR/IR for structural confirmation, to ensure it meets the high standards required for advanced synthetic applications. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support cGMP compliance for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.