Description

Nitrotyrosine Ethyl Ester CAS NO 53497-45-3 is a chemically modified derivative of the amino acid tyrosine, specifically an ethyl ester of 3-nitrotyrosine. This compound serves as a crucial biochemical tool and synthetic intermediate, valued for its role in studying nitrosative stress and protein modifications. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for applications ranging from analytical standards to the synthesis of more complex bioactive molecules.

Application

• Biochemical Research Standard: Used as a reference standard in mass spectrometry and chromatography for the detection and quantification of protein nitration, a marker of oxidative stress.
• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates targeting inflammatory and neurodegenerative pathways.
• Proteomics & Diagnostics: Employed in the development of assays and diagnostic kits to study post-translational modifications and disease mechanisms.
• Enzyme Inhibition Studies: Acts as a substrate analog or inhibitor in enzymatic studies related to tyrosine metabolism and nitration processes.
• Antibody Production: Utilized as a hapten for generating specific antibodies against nitrotyrosine epitopes for immunohistochemistry and ELISA.
• Nutritional Science Research: Applied in studies investigating the impact of dietary nitrates and nitrites on protein function and health.

Basic Information

Product Name	Nitrotyrosine Ethyl Ester
CAS No.	53497-45-3
Molecular Formula	C11H14N2O5
Molecular Weight	254.24 g/mol
Synonyms	3-Nitro-L-tyrosine ethyl ester; L-Tyrosine, 3-nitro-, ethyl ester; Ethyl 3-nitro-L-tyrosinate; O4-Nitro-L-tyrosine ethyl ester; 2-Amino-3-(4-hydroxy-3-nitrophenyl)propanoic acid ethyl ester; (2S)-2-Amino-3-(4-hydroxy-3-nitrophenyl)propanoic acid ethyl ester; NTEE
EINECS	Contact for details

Quality Control

Our Nitrotyrosine Ethyl Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the high standards required for research and synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.