Description

1,2,3-Tris(Trimethylsilyl)-1-[(Trimethylsilyl)Oxy]Isourea is a specialized organosilicon reagent primarily used as a versatile silylating agent and a key intermediate in advanced organic synthesis. Its value lies in its ability to efficiently introduce trimethylsilyl (TMS) protecting groups, facilitating complex reactions in sensitive molecule construction. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where precise control over reaction pathways is critical.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly for protecting hydroxyl and amine functionalities during multi-step processes.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where silylation steps are required for selectivity and yield improvement.
• Peptide Chemistry: Employed as a coupling agent or protecting group reagent in the synthesis of peptides and modified amino acids.
• Nucleoside & Carbohydrate Chemistry: Facilitates the protection of sensitive hydroxyl groups in the synthesis of nucleoside analogs and complex sugars.
• Material Science Precursor: Serves as a precursor or surface-modifying agent in the development of silicon-based polymers and hybrid materials.
• Laboratory Reagent: A valuable tool for academic and industrial R&D chemists exploring new synthetic methodologies involving silyl transfer reactions.

Basic Information

Product Name	1,2,3-Tris(Trimethylsilyl)-1-[(Trimethylsilyl)Oxy]Isourea
CAS No.	53460-67-6
Molecular Formula	C13H35N2O2Si4
Molecular Weight	377.80 g/mol
Synonyms	1,2,3-Tris(trimethylsilyl)-1-[(trimethylsilyl)oxy]isourea; 1,2,3-Tris(trimethylsilyl)-1-(trimethylsiloxy)isourea; 1-(Trimethylsiloxy)-1,2,3-tris(trimethylsilyl)isourea; Tris(trimethylsilyl) (trimethylsiloxy)isourea; TMS-Isourea Derivative; Silylated Isourea Reagent; O-Trimethylsilyl-N,N',N''-tris(trimethylsilyl)isourea
EINECS	Contact for details

Quality Control

Our 1,2,3-Tris(Trimethylsilyl)-1-[(Trimethylsilyl)Oxy]Isourea is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. We adhere to current Good Manufacturing Practices (cGMP) where applicable. Comprehensive analytical testing, including HPLC, GC, and NMR, is performed to verify identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation upon prolonged exposure to air. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.