Description

Carboxyifosfamide is a key pharmaceutical intermediate and metabolite of the chemotherapeutic agent ifosfamide. This compound is of significant importance in the development and quality control of oncology drugs, serving as a critical reference standard and a building block for advanced therapeutic formulations. It is primarily required by pharmaceutical manufacturers, research institutions, and analytical laboratories engaged in anticancer drug synthesis, metabolic studies, and impurity profiling.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of ifosfamide and related oxazaphosphorine alkylating agents.
• Reference Standard: Used as a high-purity analytical standard for HPLC, LC-MS, and NMR to quantify ifosfamide and its metabolites in pharmacokinetic studies.
• Metabolite Research: Essential for investigating the metabolic pathways, activation, and detoxification mechanisms of ifosfamide in biological systems.
• Impurity Profiling: Employed in the identification and qualification of related substances and degradation products in ifosfamide drug substance and finished dosage forms.
• Bioanalytical Method Development: Aids in developing and validating sensitive assays for therapeutic drug monitoring in clinical settings.
• Oncology Drug Development: Supports research into novel prodrugs and targeted cancer therapies based on the ifosfamide pharmacophore.

Basic Information

Product Name	Carboxyifosfamide
CAS No.	53459-52-2
Molecular Formula	C7H15Cl2N2O4P
Molecular Weight	293.09 g/mol
Synonyms	3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide-4-carboxylic acid; 4-Carboxyifosfamide; NSC 351958; Carboxy Ifosfamide; Ifosfamide Carboxylic Acid Metabolite; Dechloroethyl-ifosfamide Acid
EINECS	Contact for details

Quality Control

Our Carboxyifosfamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by IR and NMR, purity assay by HPLC, and control of related substances and residual solvents, to ensure it meets stringent specifications for pharmaceutical research. Certificates of Analysis (COA) with full traceability are provided and can be tailored to meet specific pharmacopeial or client requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect this light-sensitive material from moisture and contamination.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.