Description

L-Norvaline, n-(Trimethylsilyl)-5-[(Trimethylsilyl)Oxy]-, Trimethylsil Yl Ester is a specialized, high-purity silylated derivative of the non-proteinogenic amino acid L-norvaline. This compound is engineered to provide enhanced stability and solubility in organic synthesis, serving as a crucial protected intermediate. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and advanced chemical synthesis industries for the production of novel peptides, peptidomimetics, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used as a protected amino acid derivative in solid-phase and solution-phase peptide synthesis to prevent unwanted side reactions.
• Proteomics Research: Employed in biochemical research for studying protein structure, function, and enzyme-substrate interactions.
• Chemical Biology: Serves as a tool compound for developing enzyme inhibitors, receptor ligands, and other biologically active probes.
• Advanced Organic Synthesis: Acts as a versatile intermediate for introducing the norvaline moiety into complex molecular architectures under mild conditions.
• Process Chemistry: Valued in scale-up and process optimization for its defined purity and consistent performance in multi-step syntheses.

Basic Information

Product Name	L-Norvaline, n-(Trimethylsilyl)-5-[(Trimethylsilyl)Oxy]-, Trimethylsil Yl Ester
CAS No.	53261-79-3
Molecular Formula	C17H41NO3Si3
Molecular Weight	403.78 g/mol
Synonyms	L-Norvaline, N,O,O-tris(trimethylsilyl)-; N,O,O-Tris(trimethylsilyl)-L-norvaline; L-Norvaline tris(trimethylsilyl) ester; (2S)-2-[(Trimethylsilyl)amino]-5-[(trimethylsilyl)oxy]pentanoic acid trimethylsilyl ester; Tris(trimethylsilyl) L-norvalinate; Norvaline TMS derivative; Protected L-norvaline; Amino acid silylating agent
EINECS	Contact for details

Quality Control

Our L-Norvaline, n-(Trimethylsilyl)-5-[(Trimethylsilyl)Oxy]-, Trimethylsil Yl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.