Description

Mefloquine CAS NO 53230-10-7 is a synthetic quinoline methanol derivative, recognized as a critical antimalarial agent. Its primary value lies in its potent activity against chloroquine-resistant strains of *Plasmodium falciparum*, making it a cornerstone for malaria prophylaxis and treatment. This pharmaceutical active ingredient is essential for manufacturers in the global pharmaceutical industry, particularly those producing prescription medications for travelers and populations in endemic regions.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active component in antimalarial tablet formulations.
• Malaria Prophylaxis: Manufacture of prescription drugs for the prevention of malaria in travelers to endemic areas.
• Malaria Treatment: Used in the production of medications for the treatment of acute, uncomplicated malaria caused by *P. falciparum* and *P. vivax*.
• Combination Therapies: Serves as a key component in the development of fixed-dose combination antimalarial drugs to combat resistance.
• Clinical Research: Utilized as a reference standard in pharmacological and parasitological research studies.
• Veterinary Medicine: Potential application in veterinary pharmaceuticals for protozoal infections.

Basic Information

Product Name	Mefloquine
CAS No.	53230-10-7
Molecular Formula	C17H16F6N2O
Molecular Weight	378.31 g/mol
Synonyms	Mefloquine Hydrochloride; Lariam®; WR 142,490; Mephaquine; (RS)-Mefloquine; (±)-Mefloquine; 2,8-Bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol; α-(2-Piperidyl)-2,8-bis(trifluoromethyl)-4-quinolinemethanol
EINECS	Contact for details

Quality Control

Our Mefloquine is manufactured under strict quality management systems to meet the rigorous standards of the pharmaceutical industry. Quality is assured through comprehensive analytical testing, including HPLC for assay and impurity profiling, in compliance with relevant pharmacopeial monographs (e.g., USP, Ph. Eur.). A Certificate of Analysis (COA) detailing purity, identity, and specific tests is provided with each batch to ensure traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to protect from moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to almost white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Specific Optical Rotation	-0.10° to +0.10° (c=1 in methanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.