Description

(5Z,13E,15S)-15-[[(tert-Butyl)Dimethylsilyl]Oxy]-9-Oxo-5,10,13-Prostatrien-1-Oic Acid Methyl Ester is a key synthetic intermediate in the production of prostaglandin analogs and other bioactive lipid mediators. This compound is valued for its high chemical purity and structural integrity, which are critical for ensuring the efficacy and safety of downstream pharmaceutical products. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of advanced therapeutics, particularly in the fields of inflammation, ophthalmology, and reproductive health.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of prostaglandin-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a reference standard and precursor in studies investigating eicosanoid signaling pathways and receptor interactions.
• Process Development: Serves as a key material for scaling up and optimizing synthetic routes in process chemistry within GMP environments.
• Advanced Drug Discovery: Employed in medicinal chemistry programs to create novel analogs with targeted biological activity.

Basic Information

Product Name	(5Z,13E,15S)-15-[[(tert-Butyl)Dimethylsilyl]Oxy]-9-Oxo-5,10,13-Prostatrien-1-Oic Acid Methyl Ester
CAS No.	53122-04-6
Molecular Formula	C26H42O5Si
Molecular Weight	462.70 g/mol
Synonyms	9-Oxo-15-(tert-butyldimethylsilyloxy)-5Z,10,13E-prostatrienoic Acid Methyl Ester; Methyl 15-[(tert-Butyldimethylsilyl)oxy]-9-oxoprosta-5Z,10,13E-trien-1-oate; 15-TBDMS-PGE2 Methyl Ester; Prostaglandin E2 15-TBDMS Methyl Ester; 15-O-(tert-Butyldimethylsilyl)-9-oxo-PGE2 Methyl Ester; PGE2 15-TBS Methyl Ester; CAS 53122-04-6
EINECS	Contact for details

Quality Control

Our production of this advanced synthetic intermediate adheres to strict quality management systems. Every batch is characterized using advanced analytical techniques including HPLC, GC, and NMR to ensure structural identity and high chemical purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.