Description

2-Adamantyl Chloroformate is a versatile and highly reactive chemical building block used for the introduction of the sterically bulky and lipophilic 2-adamantyloxycarbonyl (2-Adoc) protecting group. This compound matters for its ability to provide exceptional stability under acidic conditions while allowing for selective deprotection under mild basic or reductive environments, which is critical for complex multi-step syntheses. It is primarily needed by researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of peptides, active pharmaceutical ingredients (APIs), and specialty polymers.

Application

• Peptide Synthesis: As a key reagent for introducing the 2-Adoc protecting group on amine functionalities, particularly valuable in solid-phase peptide synthesis (SPPS) to prevent racemization.
• Pharmaceutical Intermediates: Used in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs) where orthogonal protection strategies are required.
• Agrochemical Research: Employed in the development of novel pesticides and herbicides, leveraging the stability of the adducts for prolonged field efficacy.
• Specialty Polymers & Materials Science: Serves as a monomer or modifying agent to create polymers with unique thermal and chemical resistance properties.
• Chemical Biology & Proteomics: Utilized in the design and synthesis of activity-based probes and bioconjugates for studying enzyme function.
• Custom Synthesis & Process Development: A critical tool for contract research and manufacturing organizations (CROs/CMOs) developing bespoke synthetic routes for clients.

Basic Information

Product Name	2-Adamantyl Chloroformate
CAS No.	53120-53-9
Molecular Formula	C11H15ClO2
Molecular Weight	214.69 g/mol
Synonyms	2-Adamantyl Chloroformate; 2-Adamantyloxycarbonyl Chloride; 2-Adoc-Cl; Chloroformic Acid 2-Adamantyl Ester; 2-Adamantyl Carbonochloridate; 1,3-Dehydro-2-adamantyl Chloroformate; 2-Adamantanecarbonyl Chloride (related); 2-Adamantyloxycarbonyl Chloride
EINECS	Contact for details

Quality Control

Our 2-Adamantyl Chloroformate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports applications in GMP and research-grade environments, ensuring reliable performance in your most sensitive syntheses.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at temperatures between 2°C and 8°C (refrigerated) for long-term stability. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to reach room temperature before opening to prevent moisture condensation. Keep away from heat, sparks, open flames, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	40°C - 45°C
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.