Description

2-Bromonicotinic Acid Ethyl Ester is a versatile brominated nicotinate derivative, serving as a crucial synthetic intermediate in advanced organic chemistry. Its value lies in providing a reactive halogen handle and an ester-protected carboxylic acid group, enabling precise molecular construction. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for constructing complex heterocyclic scaffolds and active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the nicotinic acid moiety is a common pharmacophore.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in metal-catalyzed cross-coupling reactions.
• Material Science Research: Employed in the synthesis of functionalized organic molecules for electronic materials or liquid crystals.
• Chemical Biology Probes: Useful for creating tagged or modified molecules to study biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses producing high-value, low-volume specialty chemicals for clients.

Basic Information

Product Name	2-Bromonicotinic Acid Ethyl Ester
CAS No.	53087-78-8
Molecular Formula	C8H8BrNO2
Molecular Weight	230.06 g/mol
Synonyms	Ethyl 2-Bromonicotinate; 2-Bromo-3-pyridinecarboxylic Acid Ethyl Ester; 2-Bromopyridine-3-carboxylic Acid Ethyl Ester; 3-Pyridinecarboxylic Acid, 2-Bromo-, Ethyl Ester; Ethyl 2-Bromo-3-pyridinecarboxylate; 2-Bromonicotinic Acid Ethyl Ester; Ethyl 2-Bromonicotinoate; 53087-78-8
EINECS	Contact for details

Quality Control

Our 2-Bromonicotinic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and GC for residual solvent analysis, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.