Description

(4R)-2,6-Dimethyl-4-(2-Nitrophenyl)-3,4-Dihydropyridine-3,5-Dicarbonitrile is a chiral, high-purity dihydropyridine derivative of significant interest in advanced organic synthesis. This compound serves as a critical pharmaceutical intermediate and a versatile chiral building block for the development of novel active compounds. It is primarily required by research institutions and chemical manufacturers engaged in the development of cardiovascular drugs, neurological agents, and other fine chemicals where stereochemical control is paramount.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of calcium channel blockers and other cardiovascular therapeutics.
• Asymmetric Synthesis: Acts as a chiral scaffold or ligand in catalytic asymmetric reactions to induce stereoselectivity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new drug candidates.
• Chemical Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Fine Chemical Synthesis: Building block for creating complex molecules with potential biological activity in agrochemical and material science research.

Basic Information

Product Name	(4R)-2,6-Dimethyl-4-(2-Nitrophenyl)-3,4-Dihydropyridine-3,5-Dicarbonitrile
CAS No.	53055-16-6
Molecular Formula	C₁₆H₁₄N₄O₂
Molecular Weight	294.31 g/mol
Synonyms	(4R)-4-(2-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarbonitrile; (R)-4-(2-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarbonitrile; (R)-Hantzsch Ester derivative; 1,4-Dihydropyridine-3,5-dicarbonitrile, 4-(2-nitrophenyl)-2,6-dimethyl-, (4R)-; (R)-2,6-Dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarbonitrile; (R)-DHP derivative; Chiral DHP nitrile; Light-sensitive DHP intermediate.
EINECS	Contact for details

Quality Control

Our (4R)-2,6-Dimethyl-4-(2-Nitrophenyl)-3,4-Dihydropyridine-3,5-Dicarbonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure high chemical and enantiomeric purity. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability and batch-to-batch consistency, meeting the stringent requirements of research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.