Description

2,4,5-Trichlorophenyl n-[n-[(1,1-Dimethylethoxy)Carbonyl]-L-Alanyl]Glycinate is a sophisticated Boc-protected amino acid derivative that serves as a critical building block in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring high-purity intermediates for the construction of complex peptides and other bioactive molecules. It is primarily utilized in pharmaceutical R&D, process chemistry, and the production of specialized fine chemicals where precise molecular architecture is paramount.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) for the controlled incorporation of specific amino acid sequences.
• Protecting Group Strategy: The tert-butoxycarbonyl (Boc) group provides orthogonal protection for amine functionalities during multi-step synthetic routes.
• Bioconjugation: Employed in the development of peptide-protein conjugates, antibody-drug conjugates (ADCs), and other biopharmaceutical constructs.
• Chemical Biology Research: A valuable tool for probing biological systems and developing enzyme inhibitors or receptor modulators.
• Fine Chemical Synthesis: Serves as a specialized intermediate for custom synthesis and contract manufacturing organizations (CMOs).

Basic Information

Product Name	2,4,5-Trichlorophenyl n-[n-[(1,1-Dimethylethoxy)Carbonyl]-L-Alanyl]Glycinate
CAS No.	53054-11-8
Molecular Formula	C₁₆H₁₉Cl₃N₂O₅
Molecular Weight	425.69 g/mol
Synonyms	Boc-L-Ala-Gly-2,4,5-Trichlorophenyl Ester; N-[(1,1-Dimethylethoxy)carbonyl]-L-alanylglycine 2,4,5-Trichlorophenyl Ester; Boc-Ala-Gly-O-2,4,5-Trichlorophenyl; Boc-L-Alanyl-Glycine 2,4,5-Trichlorophenyl Ester; tert-Butoxycarbonyl-L-alanylglycine 2,4,5-Trichlorophenyl Ester; (2,4,5-Trichlorophenoxy)carbonyl Boc-L-Ala-Gly; Boc-Ala-Gly-OTcp; Boc-L-Ala-Gly-OTcp Ester
EINECS	Contact for details

Quality Control

Our 2,4,5-Trichlorophenyl n-[n-[(1,1-Dimethylethoxy)Carbonyl]-L-Alanyl]Glycinate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and chiral purity, to meet the exacting standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.