Description

[2-Methyl-1-[(Trimethylsilyl)Amino]Propyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is a specialized organosilicon-protected phosphonic acid derivative that serves as a critical intermediate in advanced synthetic chemistry. Its value lies in its dual functionality, offering a protected phosphonate group and a silylated amine, which enables precise and efficient construction of complex molecules under mild conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries who require high-purity, reactive intermediates for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those containing phosphonate or aminophosphonate pharmacophores.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators that require phosphonate functionality.
• Ligand and Catalyst Precursor: Serves as a precursor for creating sophisticated ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Peptide Mimetics and Prodrug Development: Employed in the design of phosphonate-based peptide analogs and prodrugs to enhance bioavailability and metabolic stability.
• Material Science Research: Utilized in the surface modification of materials and the synthesis of hybrid organic-inorganic polymers and coatings.
• Chemical Biology Probes: Acts as a versatile handle for introducing phosphonate groups into biomolecules for mechanistic studies and diagnostic applications.

Basic Information

Product Name	[2-Methyl-1-[(Trimethylsilyl)Amino]Propyl]Phosphonic Acid Bis(Trimethylsilyl) Ester
CAS No.	53044-41-0
Molecular Formula	C13H34NO3PSi3
Molecular Weight	367.65 g/mol
Synonyms	Bis(trimethylsilyl) [2-methyl-1-[(trimethylsilyl)amino]propyl]phosphonate; Phosphonic acid, P-[2-methyl-1-[(trimethylsilyl)amino]propyl]-, bis(trimethylsilyl) ester; (2-Methyl-1-((trimethylsilyl)amino)propyl)phosphonic acid bis(trimethylsilyl) ester; TMS-protected aminophosphonate; Silylated Aminopropylphosphonate Ester
EINECS	Contact for details

Quality Control

Our production of [2-Methyl-1-[(Trimethylsilyl)Amino]Propyl]Phosphonic Acid Bis(Trimethylsilyl) Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and purity for demanding synthetic applications. Each lot undergoes comprehensive analysis using advanced techniques including NMR, HPLC, and GC-MS. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) to prevent degradation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.