Description

[1-[(Trimethylsilyl)Amino]Pentyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is a specialized organosilicon-protected phosphonic acid derivative, a key building block in advanced organic synthesis. Its value lies in its dual functionality, offering a protected amino group and a phosphonate moiety, which is crucial for constructing complex molecules with precise stereochemistry. This compound is essential for researchers and manufacturers in pharmaceutical development, agrochemical synthesis, and materials science who require high-purity intermediates for peptide mimetics, prodrugs, and ligand synthesis.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly for bone-targeting bisphosphonate analogs and peptide-based therapeutics.
• Agrochemical Synthesis: Used in the development of advanced herbicides and plant growth regulators that utilize phosphonate chemistry for enhanced activity and stability.
• Ligand and Catalyst Preparation: Serves as a versatile building block for creating complex chelating ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Peptidomimetic Research: Enables the incorporation of non-hydrolyzable phosphonate linkages into peptide chains to create stable enzyme inhibitors and bioactive probes.
• Surface Modification Agent: Used to functionalize silica and other metal oxide surfaces for specialized chromatography media and advanced composite materials.
• Chemical Biology Tool: Employed in the synthesis of activity-based probes and affinity labels for studying enzyme mechanisms and protein interactions.

Basic Information

Item	Details
Product Name	[1-[(Trimethylsilyl)Amino]Pentyl]Phosphonic Acid Bis(Trimethylsilyl) Ester
CAS No.	53044-40-9
Molecular Formula	C14H36NO3PSi3
Molecular Weight	381.67 g/mol
Synonyms	5-[(Bis(trimethylsilyl)oxy)phosphinyl]-1-(trimethylsilyl)aminopentane; Phosphonic acid, P-[1-[(trimethylsilyl)amino]pentyl]-, bis(trimethylsilyl) ester; N-(Trimethylsilyl)-5-[(bis(trimethylsilyl)oxy)phosphinyl]-1-pentanamine; (1-Trimethylsilylaminopentyl)phosphonic Acid Bis(trimethylsilyl) Ester; TMS-Protected Aminopentylphosphonate
EINECS	Contact for details

Quality Control

Our [1-[(Trimethylsilyl)Amino]Pentyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical characterization, including NMR (¹H, ¹³C, ³¹P), HPLC, and GC analysis, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full spectral data are provided for every shipment, supporting cGMP and ISO-guided research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) to prevent decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.