Description

[[(Trimethylsilyl)Amino]Methyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is a specialized organosilicon-protected phosphonic acid derivative, serving as a key synthetic intermediate in advanced organic and organometallic chemistry. Its value lies in its dual functionality, offering a protected amino-methyl phosphonate group that is highly reactive yet stable under a range of conditions, enabling precise molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science sectors, particularly for the synthesis of complex molecules, metal-chelating ligands, and novel functional materials.

Application

• Pharmaceutical Intermediate: Used in the synthesis of novel drug candidates, particularly those containing phosphonate or bisphosphonate moieties for therapeutic applications.
• Ligand Synthesis: Serves as a precursor for creating sophisticated chelating ligands used in catalysis, metal-organic frameworks (MOFs), and coordination chemistry.
• Agrochemical Research: Employed in developing advanced active ingredients, such as herbicides or plant growth regulators, that utilize phosphonate chemistry.
• Surface Modification Agent: Acts as a coupling agent or surface modifier for inorganic materials like silica or metals, imparting specific functional groups.
• Polymer & Materials Science: Incorporated into the synthesis of specialty polymers, dendrimers, or hybrid organic-inorganic materials with tailored properties.
• Peptide Mimetics & Bio-conjugates: Used to introduce phosphonate isosteres into peptides or to create bioconjugates for biochemical research and diagnostic applications.

Basic Information

Item	Detail
Product Name	[[(Trimethylsilyl)Amino]Methyl]Phosphonic Acid Bis(Trimethylsilyl) Ester
CAS No.	53044-36-3
Molecular Formula	C10H28NO3PSi3
Molecular Weight	325.56 g/mol
Synonyms	[[(Trimethylsilyl)Amino]Methyl]Phosphonic Acid Bis(Trimethylsilyl) Ester; Phosphonic acid, P-[[(trimethylsilyl)amino]methyl]-, bis(trimethylsilyl) ester; (Aminomethyl)phosphonic Acid Tris(trimethylsilyl) Derivative; Tris(trimethylsilyl) (Aminomethyl)phosphonate; N-(Trimethylsilyl)aminomethylphosphonic Acid Bis(trimethylsilyl) Ester; TMS-Protected Aminomethylphosphonate
EINECS	Contact for details

Quality Control

Our production of [[(Trimethylsilyl)Amino]Methyl]Phosphonic Acid Bis(Trimethylsilyl) Ester adheres to stringent in-process controls to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques, including NMR, HPLC, and GC, to confirm identity and quantify impurities. Certificates of Analysis (COA) detailing all relevant specifications are provided with every shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.