Description

[1-Amino-2-[4-[(Trimethylsilyl)Oxy]Phenyl]Ethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is a sophisticated organosilicon-protected phosphonate derivative, serving as a critical synthetic intermediate. Its value lies in its dual-protected functional groups, which provide enhanced stability and controlled reactivity for advanced organic synthesis. This compound is essential for researchers and manufacturers in pharmaceutical development, agrochemical research, and materials science who require high-purity, specialized building blocks for complex molecule construction.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting bone-related disorders or requiring phosphonate functionality.
• Agrochemical Research: Used in developing advanced herbicides, plant growth regulators, or fungicides that incorporate aminophosphonate motifs for enhanced bioactivity.
• Ligand Synthesis: Precursor for creating specialized chelating agents, catalysts, or metal-organic frameworks (MOFs) in coordination chemistry and materials science.
• Peptidomimetics & Prodrug Development: Employed in medicinal chemistry to create phosphonate-based peptide analogs or to design prodrugs with improved bioavailability.
• Chemical Biology Probes: Useful for synthesizing activity-based probes or inhibitors to study enzyme mechanisms, particularly those involving phosphate or phosphonate recognition.
• Advanced Material Monomers: Serves as a monomer or cross-linker in the synthesis of specialty polymers, resins, or surface-modifying agents with unique properties.

Basic Information

Product Name	[1-Amino-2-[4-[(Trimethylsilyl)Oxy]Phenyl]Ethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester
CAS No.	53044-35-2
Molecular Formula	C17H34NO4PSi3
Molecular Weight	419.68 g/mol
Synonyms	Phosphonic acid, [1-amino-2-[4-[(trimethylsilyl)oxy]phenyl]ethyl]-, bis(trimethylsilyl) ester; 1-Amino-2-(4-trimethylsiloxyphenyl)ethylphosphonic Acid Bis(trimethylsilyl) Ester; (1-Amino-2-(4-(trimethylsilyloxy)phenyl)ethyl)phosphonic Acid Bis(trimethylsilyl) Ester; ATMP-TMS Ester; Aminoarylphosphonate TMS Derivative; Contact for details on additional trade names or abbreviations.
EINECS	Contact for details

Quality Control

Our production of [1-Amino-2-[4-[(Trimethylsilyl)Oxy]Phenyl]Ethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or viscous oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 0.5% w/w
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.