Description

Bis(Trimethylsilyl)=(1-Amino-2-Phenylethyl) Phosphonate is a specialized organosilicon phosphonate derivative, serving as a key protected intermediate in advanced organic synthesis. Its primary value lies in enabling the controlled introduction of the 1-amino-2-phenylethyl phosphonate moiety, a crucial building block for bioactive molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of peptide mimetics, enzyme inhibitors, and novel drug candidates.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of phosphonate-based protease inhibitors and other bioactive compounds.
• Peptidomimetic Synthesis: Used to incorporate non-hydrolyzable phosphonate groups into peptide analogs, enhancing metabolic stability.
• Agrochemical Research: Serves as a precursor in the development of novel herbicides and plant growth regulators with phosphonate activity.
• Medicinal Chemistry: Enables the exploration of structure-activity relationships (SAR) in drug discovery programs targeting various enzymes.
• Chemical Biology Probes: Utilized in the creation of activity-based probes and inhibitors for studying phosphonate-dependent biological pathways.
• Custom Synthesis: Employed by contract research organizations (CROs) and fine chemical manufacturers for client-specific molecule development.

Basic Information

Product Name	Bis(Trimethylsilyl)=(1-Amino-2-Phenylethyl) Phosphonate
CAS No.	53044-34-1
Molecular Formula	C14H26NO3PSi2
Molecular Weight	343.51 g/mol
Synonyms	(1-Amino-2-phenylethyl)phosphonic Acid Bis(trimethylsilyl) Ester; Phosphonic Acid, P-(1-Amino-2-phenylethyl)-, Bis(trimethylsilyl) Ester; 1-Amino-2-phenylethylphosphonic Acid Bis(trimethylsilyl) Ester; TMS-Protected 1-Amino-2-phenylethylphosphonate; Bis(TMS) (1-Amino-2-phenylethyl)phosphonate; (α-Aminobenzyl)phosphonic Acid Bis(trimethylsilyl) Ester
EINECS	Contact for details

Quality Control

Every batch of Bis(Trimethylsilyl)=(1-Amino-2-Phenylethyl) Phosphonate is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent performance for synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.