Description

(1-Aminopentyl)Phosphonic Acid Bis(Trimethylsilyl) Ester is a protected phosphonate derivative, a crucial intermediate in advanced organic synthesis. Its primary value lies in its role as a key synthon for the preparation of α-aminophosphonic acids and their analogs, which are compounds of significant interest in medicinal chemistry and agrochemical research. This product is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity building blocks for drug discovery and the development of biologically active molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of α-aminophosphonic acid derivatives, which are potent enzyme inhibitors and potential drug candidates for treating various diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators based on phosphonate chemistry.
• Peptidomimetics Research: Serves as a phosphonate analog of amino acids for creating stable peptide mimics with enhanced biological activity and metabolic stability.
• Ligand and Catalyst Development: Employed in the preparation of chelating ligands and organocatalysts for asymmetric synthesis and metal complexation.
• Material Science Precursor: Can be utilized in the surface modification of materials or the synthesis of functional polymers and coatings.
• Chemical Biology Probes: Acts as a building block for creating activity-based probes and other tools to study phosphonate-related biochemical pathways.

Basic Information

Item	Detail
Product Name	(1-Aminopentyl)Phosphonic Acid Bis(Trimethylsilyl) Ester
CAS No.	53044-32-9
Molecular Formula	C11H28NO3PSi2
Molecular Weight	309.49 g/mol
Synonyms	5-Aminopentylphosphonic Acid Bis(trimethylsilyl) Ester; 1-Amino-5-pentylphosphonic Acid Bis(TMS) Ester; Bis(trimethylsilyl) (5-aminopentyl)phosphonate; Pentyl-1-aminophosphonic Acid Bis(trimethylsilyl) Ester; (5-Aminopentyl)phosphonic Acid Bis(trimethylsilyl) Ester; Phosphonic Acid, P-(1-aminopentyl)-, bis(trimethylsilyl) ester
EINECS	Contact for details

Quality Control

Our (1-Aminopentyl)Phosphonic Acid Bis(Trimethylsilyl) Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC analysis, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality parameters. Our commitment to cGMP principles and rigorous in-process controls guarantees a reliable supply of this high-value synthetic intermediate.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.