Description

(1-Aminobutyl)Phosphonic Acid Bis(Trimethylsilyl) Ester is a specialized organosilicon-protected phosphonate derivative, serving as a key synthetic intermediate and protecting group reagent. This compound is valued for its role in facilitating complex organic transformations, particularly in the synthesis of bioactive molecules and novel materials, by safeguarding reactive phosphonic acid functionalities. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Used in the synthesis of novel drug candidates, particularly those containing aminophosphonate or bisphosphonate moieties with potential biological activity.
• Agrochemical Research: Serves as a building block for developing new herbicides, plant growth regulators, and other crop protection agents.
• Peptide Mimetics & Prodrug Synthesis: Acts as a protected precursor for incorporating phosphonate groups into peptide analogs and prodrug formulations to enhance stability or bioavailability.
• Material Science Precursor: Employed in the development of functionalized surfaces, metal-organic frameworks (MOFs), and other advanced materials where a protected phosphonic acid group is required.
• Organocatalysis & Ligand Design: Utilized as a starting material for creating novel chiral catalysts or ligands for asymmetric synthesis.
• Chemical Biology Probes: Functions as a key reagent in the preparation of activity-based probes or inhibitors for studying enzyme mechanisms, particularly phosphatases and kinases.

Basic Information

Product Name	(1-Aminobutyl)Phosphonic Acid Bis(Trimethylsilyl) Ester
CAS No.	53044-31-8
Molecular Formula	C10H28NO3PSi2
Molecular Weight	309.48 g/mol
Synonyms	4-Aminobutylphosphonic Acid Bis(trimethylsilyl) Ester; 4-Amino-1-bis(trimethylsilyloxy)phosphorylbutane; (4-Aminobutyl)phosphonic Acid Bis-O-(trimethylsilyl) Ester; Phosphonic Acid, P-(4-aminobutyl)-, Bis(trimethylsilyl) Ester; ABP-BTSE; 1-Amino-4-(bis(trimethylsiloxy)phosphoryl)butane
EINECS	Contact for details

Quality Control

Our (1-Aminobutyl)Phosphonic Acid Bis(Trimethylsilyl) Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including NMR (¹H, ¹³C, ³¹P), HPLC, and GC analysis, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your research and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.