Description

Bis(Trimethylsilyl)=(1-Aminopropyl) Phosphonate is a specialized organosilicon phosphonate compound that serves as a versatile reagent and building block in advanced synthesis. Its value lies in its dual functionality, combining a silyl-protected phosphonate group with a primary amine, enabling its use in the preparation of complex molecules and materials. This chemical is primarily needed by researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries for applications such as peptide mimetics, prodrug development, and surface modification.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly those involving phosphonate or aminophosphonate pharmacophores.
• Peptidomimetic Synthesis: Used to create stable phosphonate analogs of amino acids and peptides for biochemical research and drug development.
• Prodrug Development: Employed in the design of prodrugs where the silyl groups can be cleaved under specific physiological conditions.
• Agrochemical Research: Serves as an intermediate in the synthesis of new herbicides, pesticides, and plant growth regulators.
• Surface Modification Agent: Utilized to functionalize silica, glass, or other surfaces with amine and phosphonate groups for specialized coatings.
• Ligand and Catalyst Preparation: Acts as a precursor for chelating ligands used in metal catalysis and coordination chemistry.
• Polymer and Material Science: Incorporated into polymers to impart specific properties like flame retardancy, adhesion, or biocompatibility.
• Cross-coupling Reagent: Can be used in Horner-Wadsworth-Emmons or related olefination reactions for carbon-carbon bond formation.

Basic Information

Product Name	Bis(Trimethylsilyl)=(1-Aminopropyl) Phosphonate
CAS No.	53044-30-7
Molecular Formula	C9H26NO3PSi2
Molecular Weight	283.45 g/mol
Synonyms	(1-Aminopropyl)phosphonic Acid Bis(trimethylsilyl) Ester; 1-Aminopropylphosphonic Acid Bis(trimethylsilyl) Ester; Bis(trimethylsilyl) 1-Aminopropylphosphonate; 3-Aminopropylphosphonic Acid Bis(trimethylsilyl) Ester; O,O-Bis(trimethylsilyl) (3-aminopropyl)phosphonate; Phosphonic Acid, P-(3-aminopropyl)-, Bis(trimethylsilyl) Ester; APTMS Phosphonate Derivative; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our Bis(Trimethylsilyl)=(1-Aminopropyl) Phosphonate is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are available upon request. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.