Description

Bis(Trimethylsilyl)=(Aminomethyl) Phosphonate is a specialized organosilicon reagent featuring a unique phosphonate ester group protected by trimethylsilyl moieties. This compound is valued for its role as a key synthetic intermediate and protecting group in advanced organic and medicinal chemistry. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Used in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those containing phosphonate or aminomethylphosphonate bioisosteres.
• Peptide Mimetics & Prodrug Synthesis: Serves as a building block for creating peptide analogs and designing prodrug strategies to enhance drug delivery and bioavailability.
• Agrochemical Research: Employed in the development of new herbicides, fungicides, and plant growth regulators that incorporate phosphonate functionality.
• Ligand & Catalyst Preparation: Acts as a precursor for synthesizing specialized phosphonate-based ligands used in catalysis and metal coordination chemistry.
• Surface Modification Agent: Utilized in materials science to functionalize surfaces with specific organic groups for tailored adhesion or reactivity properties.
• Chemical Biology Probes: Incorporated into molecular probes for studying enzyme mechanisms, particularly those involving phosphate transfer.

Basic Information

Product Name	Bis(Trimethylsilyl)=(Aminomethyl) Phosphonate
CAS No.	53044-29-4
Molecular Formula	C7H22NO3PSi2
Molecular Weight	255.40 g/mol
Synonyms	(Aminomethyl)phosphonic Acid Bis(trimethylsilyl) Ester; Phosphonic Acid, P-[(Aminomethyl)]-, Bis(trimethylsilyl) Ester; Bis(trimethylsilyl) (Aminomethyl)phosphonate; (Aminomethyl)phosphonic Acid Bis-O-(trimethylsilyl) Ester; TMS-(Aminomethyl)phosphonate; N-[(Bis(trimethylsilyloxy)phosphinyl]methyl]amine
EINECS	Contact for details

Quality Control

Our Bis(Trimethylsilyl)=(Aminomethyl) Phosphonate is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and GC, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.