Description

3-[Bis[(Trimethylsilyl)Oxy]Phosphinyl]Propionic Acid Trimethylsilyl Ester is a specialized organosilicon-protected phosphonic acid derivative, serving as a critical synthetic intermediate and protecting group reagent. Its primary value lies in enabling complex organic synthesis, particularly in the construction of sensitive molecules where standard phosphonic acid chemistry is incompatible. This compound is essential for researchers and manufacturers in pharmaceutical development, agrochemical synthesis, and advanced material science, facilitating the creation of novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of nucleotide analogs, prodrugs, and other bioactive molecules containing phosphonate or phosphonic acid groups.
• Agrochemical Synthesis: Used in the production of modern herbicides, fungicides, and plant growth regulators that utilize phosphonate chemistry.
• Peptide & Protein Modification: Acts as a phosphorylating or functionalizing agent for amino acids and peptides under mild, silyl-protected conditions.
• Material Science Precursor: Serves as a monomer or cross-linking agent for creating specialty polymers, coatings, and surface modifiers with specific adhesion or release properties.
• Organic Synthesis Reagent: Provides a protected form of a phosphonic acid moiety for use in multi-step synthesis, including Horner-Wadsworth-Emmons and other olefination reactions.
• Ligand Synthesis: Intermediate for the preparation of complex chelating agents and catalysts used in asymmetric synthesis and metal complexation.

Basic Information

Product Name	3-[Bis[(Trimethylsilyl)Oxy]Phosphinyl]Propionic Acid Trimethylsilyl Ester
CAS No.	53044-28-3
Molecular Formula	C12H31O5PSi3
Molecular Weight	370.60 g/mol
Synonyms	Trimethylsilyl 3-[bis(trimethylsilyloxy)phosphoryl]propanoate; Propanoic acid, 3-[bis[(trimethylsilyl)oxy]phosphinyl]-, trimethylsilyl ester; 3-(Bis(trimethylsilyloxy)phosphinyl)propionic acid trimethylsilyl ester; TMS-PA propionate derivative; Silyl-protected propionylphosphonate; Tris(trimethylsilyl) 3-phosphonopropionate
EINECS	Contact for details

Quality Control

Our production of 3-[Bis[(Trimethylsilyl)Oxy]Phosphinyl]Propionic Acid Trimethylsilyl Ester adheres to stringent in-process controls to ensure batch-to-batch consistency and high purity. Each lot is analyzed via NMR, HPLC, and GC to confirm identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, and we support compliance with relevant regulatory frameworks for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.