Description

Isopropyl 5-Oxo-L-Prolinate is a high-purity, protected amino acid derivative, specifically an ester of 5-oxoproline, which serves as a critical chiral building block in advanced organic synthesis. This compound is valued for its role in constructing complex peptide mimetics and pharmaceutical intermediates, offering precise stereochemical control. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel active ingredients and specialty compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of peptide-based drugs, protease inhibitors, and other bioactive molecules.
• Peptidomimetic Research: Used in academic and industrial R&D to create and study modified peptide structures with enhanced metabolic stability or binding affinity.
• Asymmetric Synthesis: Employed as a building block in stereoselective reactions to introduce the L-proline or pyroglutamic acid scaffold into target molecules.
• Fine Chemical Production: Integral in the multi-step synthesis of complex specialty chemicals, flavors, and fragrances requiring high enantiomeric purity.
• Bioconjugation Chemistry: Can be used to develop linkers or modifiers for antibody-drug conjugates (ADCs) and other biopharmaceuticals.

Basic Information

Product Name	Isopropyl 5-Oxo-L-Prolinate
CAS No.	52989-50-1
Molecular Formula	C8H13NO4
Molecular Weight	187.19 g/mol
Synonyms	L-Pyroglutamic Acid Isopropyl Ester; Isopropyl L-Pyroglutamate; 5-Oxo-L-proline Isopropyl Ester; (S)-5-Oxopyrrolidine-2-carboxylic Acid Isopropyl Ester; Isopropyl (S)-5-oxopyrrolidine-2-carboxylate; 2-Pyrrolidinone, 5-oxo-, isopropyl ester, (S)-; Isopropyl (S)-(-)-2-pyrrolidone-5-carboxylate
EINECS	Contact for details

Quality Control

Our Isopropyl 5-Oxo-L-Prolinate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for pharmaceutical research and synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when necessary to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.