Description

[R,(+)]-α-(Trimethylsilyl)Benzenemethanol is a high-value chiral organosilicon compound, serving as a versatile chiral building block and auxiliary in advanced organic synthesis. Its unique structure, featuring a stereogenic center adjacent to a silyl-protected benzylic alcohol, makes it crucial for introducing chirality in complex molecular architectures. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the asymmetric synthesis of active ingredients and fine chemicals.

Application

• As a chiral auxiliary or ligand in asymmetric catalysis for the synthesis of enantiomerically pure pharmaceuticals.
• Key chiral intermediate in the research and development of novel active pharmaceutical ingredients (APIs).
• Building block for the preparation of silicon-containing chiral materials and liquid crystals.
• Use in methodological development for new stereoselective carbon-carbon and carbon-heteroatom bond-forming reactions.
• Precursor for chiral derivatizing agents used in analytical chemistry for enantiomeric excess determination.
• Intermediate in the synthesis of agrochemicals and other bioactive compounds requiring specific stereochemistry.

Basic Information

Product Name	[R,(+)]-α-(Trimethylsilyl)Benzenemethanol
CAS No.	52908-62-0
Molecular Formula	C10H16OSi
Molecular Weight	180.32 g/mol
Synonyms	(R)-(+)-α-(Trimethylsilyl)benzyl Alcohol; (R)-1-Phenyl-1-(trimethylsilyl)methanol; (+)-(R)-α-(Trimethylsilyl)benzenemethanol; (R)-(+)-1-Phenyl-1-(trimethylsilyl)ethanol (common misnomer); (R)-Benzylic Alcohol, α-Trimethylsilyl-; (R)-TMS-Benzyl Alcohol; (R)-α-(Trimethylsilyl)benzyl Alcohol; (1R)-1-Phenyl-1-(trimethylsilyl)methanol (IUPAC)
EINECS	Contact for details

Quality Control

Every batch of [R,(+)]-α-(Trimethylsilyl)Benzenemethanol is produced and tested under strict quality management protocols to ensure high chemical and enantiomeric purity. Our products undergo rigorous quality testing, including chiral HPLC analysis, to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profile is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.