Description

1-O,2-O,3-O,4-o-Tetrakis(Trimethylsilyl)-α-D-Glucopyranuronic Acid Trimethylsilyl Ester is a fully protected derivative of glucuronic acid, extensively utilized as a key synthetic intermediate in advanced organic and carbohydrate chemistry. This compound is critical for researchers and manufacturers requiring precise control over stereochemistry and reactivity in complex molecule assembly. It is primarily employed in the development of pharmaceuticals, specialty carbohydrates, and sophisticated chemical probes where protecting group strategy is paramount.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of glycosylated drug candidates, prodrugs, and complex bioactive molecules.
• Carbohydrate Chemistry Research: Enables the controlled functionalization and manipulation of glucuronic acid moieties for studying glycoconjugates and polysaccharides.
• Glycosylation Reactions: Acts as a protected glycosyl donor or acceptor in stereoselective glycosylation protocols to construct specific glycosidic linkages.
• Analytical Reference Standard: Used as a high-purity standard in analytical methods (HPLC, GC-MS, NMR) for identifying and quantifying related compounds.
• Bioconjugate Development: Facilitates the creation of labeled carbohydrates and linkers for diagnostic assays and targeted delivery systems.
• Material Science: Investigated for the synthesis of functionalized polymers and surfaces with carbohydrate-based recognition elements.

Basic Information

Item	Details
Product Name	1-O,2-O,3-O,4-o-Tetrakis(Trimethylsilyl)-α-D-Glucopyranuronic Acid Trimethylsilyl Ester
CAS No.	52842-25-8
Molecular Formula	C24H56O7Si5
Molecular Weight	625.18 g/mol
Synonyms	α-D-Glucopyranuronic acid, 1,2,3,4-tetrakis-O-(trimethylsilyl)-, trimethylsilyl ester; Per-O-trimethylsilyl glucuronic acid TMS ester; Glucuronic acid pentakis(trimethylsilyl) ether; TMS-glucuronate; 1,2,3,4-Tetra-O-trimethylsilyl-α-D-glucopyranuronic acid trimethylsilyl ester; Fully protected glucuronic acid TMS ester; Glucopyranuronic acid pentatrimethylsilyl derivative
EINECS	Contact for details

Quality Control

Every batch of 1-O,2-O,3-O,4-o-Tetrakis(Trimethylsilyl)-α-D-Glucopyranuronic Acid Trimethylsilyl Ester is produced and analyzed under strict quality management protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Assay	≥ 97%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.