Description

1-O,2-O,3-O,4-o-Tetrakis(Trimethylsilyl)-β-D-Glucopyranuronic Acid Trimethylsilyl Ester is a fully silylated derivative of glucuronic acid, a key intermediate in carbohydrate and glycoconjugate chemistry. This compound is essential for analytical and synthetic applications where the protection of hydroxyl and carboxylic acid groups is required to prevent unwanted side reactions and enhance volatility for techniques like gas chromatography-mass spectrometry (GC-MS). It is primarily utilized by researchers and process chemists in pharmaceutical development, analytical laboratories, and specialty chemical synthesis.

Application

• Derivatization Agent for GC-MS Analysis: Used to convert polar carbohydrates, organic acids, and related metabolites into volatile trimethylsilyl (TMS) derivatives for accurate identification and quantification.
• Pharmaceutical Intermediate: Serves as a protected building block in the synthesis of complex glycosides, prodrugs, and targeted drug conjugates.
• Biochemical Research: Employed in studies of glucuronidation pathways, metabolic profiling, and the analysis of glycoprotein structures.
• Reference Standard: Acts as a high-purity analytical standard for method development and quality control in analytical laboratories.
• Specialty Chemical Synthesis: A key precursor for creating silyl-protected sugars used in organic synthesis and material science.

Basic Information

Product Name	1-O,2-O,3-O,4-o-Tetrakis(Trimethylsilyl)-β-D-Glucopyranuronic Acid Trimethylsilyl Ester
CAS No.	52842-24-7
Molecular Formula	C22H52O7Si5
Molecular Weight	585.1 g/mol
Synonyms	Glucopyranuronic acid, 1,2,3,4-tetrakis-O-(trimethylsilyl)-, trimethylsilyl ester, β-D-; β-D-Glucopyranuronic acid, 1,2,3,4-tetrakis-O-(trimethylsilyl)-, trimethylsilyl ester; Per-O-trimethylsilyl glucuronic acid TMS ester; TMS-glucuronic acid; Glucuronic acid, per(trimethylsilyl) ether, trimethylsilyl ester; Fully silylated D-glucuronic acid; 1,2,3,4-Tetra-O-trimethylsilyl-β-D-glucopyranuronic acid trimethylsilyl ester
EINECS	Contact for details

Quality Control

Our 1-O,2-O,3-O,4-o-Tetrakis(Trimethylsilyl)-β-D-Glucopyranuronic Acid Trimethylsilyl Ester is produced and handled under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 95% (Typical 97-99%)
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.