Description

4-Amino-5-Chloronicotinic Acid is a high-purity, versatile heterocyclic building block essential for advanced organic synthesis. This compound is valued for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and other fine chemicals. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of various drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, leveraging its chloronicotinic acid backbone.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in catalytic processes and metal-organic frameworks (MOFs).
• Organic Electronic Materials: Investigated as a building block for novel materials in organic light-emitting diodes (OLEDs) and semiconductors due to its conjugated system.
• Biochemical Research: Employed in life science research for developing molecular probes, enzyme inhibitors, and other bioactive compounds.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity heterocyclic intermediates.

Basic Information

Product Name	4-Amino-5-Chloronicotinic Acid
CAS No.	52834-09-0
Molecular Formula	C6H5ClN2O2
Molecular Weight	172.57 g/mol
Synonyms	5-Chloro-4-aminonicotinic Acid; 4-Amino-5-chloropyridine-3-carboxylic Acid; 3-Carboxy-5-chloro-4-aminopyridine; 5-Chloro-4-pyridinamine-3-carboxylic Acid; 4-Amino-5-chloro-3-pyridinecarboxylic Acid; 52834-09-0; 4-Amino-5-chloro-nicotinic acid
EINECS	Contact for details

Quality Control

Our 4-Amino-5-Chloronicotinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical and fine chemical applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.