Description

4-Chloro-1-Ethyl-1H-Pyrazolo[3,4-B]Pyridine-5-Carbonyl Chloride is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its core value lies in its dual reactive sites, the acid chloride and chloro substituent, which enable efficient derivatization and incorporation into complex molecular architectures. This compound is critically needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, leveraging the pyrazolopyridine scaffold.
• Material Science Precursor: Serves as a monomer or functionalizing agent for creating specialized polymers and organic electronic materials.
• Chemical Biology Probes: Utilized to create tagged molecules for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical starting material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for clients.
• Academic & Institutional Research: Employed in universities and research institutes for methodological development and exploring new chemical spaces.

Basic Information

Product Name	4-Chloro-1-Ethyl-1H-Pyrazolo[3,4-B]Pyridine-5-Carbonyl Chloride
CAS No.	52833-03-1
Molecular Formula	C11H9Cl2N3O
Molecular Weight	270.11 g/mol
Synonyms	4-Chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl chloride; 1-Ethyl-4-chloro-1H-pyrazolo[3,4-b]pyridine-5-carbonyl chloride; 5-Chlorocarbonyl-4-chloro-1-ethylpyrazolo[3,4-b]pyridine; 4-Chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid chloride; Pyrazolo[3,4-b]pyridine-5-carbonyl chloride, 4-chloro-1-ethyl-; CAS 52833-03-1
EINECS	Contact for details

Quality Control

Our production of 4-Chloro-1-Ethyl-1H-Pyrazolo[3,4-B]Pyridine-5-Carbonyl Chloride adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. Quality is verified via modern analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.