Description

2-(2-Hydroxyethoxy)Ethyl Chloroacetate is a versatile bifunctional chemical intermediate that combines a reactive chloroacetate ester group with a terminal hydroxyl group. This unique structure makes it a valuable building block for the synthesis of more complex molecules, particularly in the pharmaceutical and specialty chemical sectors. It is primarily sought after by research chemists and process development teams for creating active pharmaceutical ingredients (APIs), functional polymers, and advanced surfactants.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs requiring polyethylene glycol (PEG) linkers or ester prodrugs.
• Polymer Chemistry: Used as a monomer or cross-linking agent for producing functional polymers, hydrogels, and coatings with tailored properties.
• Surfactant & Emulsifier Synthesis: Serves as a precursor for non-ionic surfactants and emulsifiers used in agrochemicals, personal care, and industrial formulations.
• Chemical Derivatization: Employed in organic synthesis to introduce the 2-(2-hydroxyethoxy)ethyl moiety, which can improve solubility and pharmacokinetic properties.
• Linker for Bioconjugation: Useful in bioconjugation chemistry for attaching drugs, dyes, or other molecules to proteins, peptides, or nanoparticles.
• Research & Development: A valuable reagent in academic and industrial R&D labs for exploring new synthetic pathways and novel materials.

Basic Information

Product Name	2-(2-Hydroxyethoxy)Ethyl Chloroacetate
CAS No.	52637-01-1
Molecular Formula	C6H11ClO4
Molecular Weight	182.60 g/mol
Synonyms	Ethylene glycol mono(2-chloroacetate) ethyl ether; 2-(2-Chloroacetoxyethoxy)ethanol; Chloroacetic acid 2-(2-hydroxyethoxy)ethyl ester; 2-(2-Hydroxyethoxy)ethyl 2-chloroacetate; Bis(2-hydroxyethyl) ether chloroacetate; Glycol ether chloroacetate; 1-Chloro-2-oxo-2-(2-(2-oxoethoxy)ethoxy)ethane; 2-[2-(Chloroacetoxy)ethoxy]ethanol
EINECS	Contact for details

Quality Control

Our 2-(2-Hydroxyethoxy)Ethyl Chloroacetate is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including assay by GC/HPLC, identity confirmation (IR, NMR), and impurity profiling, to ensure it meets high-purity standards suitable for sensitive applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Specific Gravity (20°C)	1.20 - 1.25
Refractive Index (20°C)	1.450 - 1.460

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.