Description

2-Bromo-3-Chloro-1,8-Naphthyridine is a halogenated naphthyridine derivative, a high-value heterocyclic building block prized for its unique reactivity profile. This compound is essential for advanced organic synthesis, particularly in the development of complex molecules with tailored electronic and steric properties. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting kinase inhibition or other biological pathways where the 1,8-naphthyridine scaffold is active.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Material Science: Serves as a building block for organic semiconductors, ligands for metal-organic frameworks (MOFs), and other functional organic materials.
• Cross-Coupling Reactions: The bromo and chloro substituents make it an excellent substrate for sequential palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce diverse functional groups.
• Ligand Synthesis: Useful for the preparation of chelating ligands in coordination chemistry and catalysis.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological systems and enzyme mechanisms.

Basic Information

Product Name	2-Bromo-3-Chloro-1,8-Naphthyridine
CAS No.	52626-32-1
Molecular Formula	C8H4BrClN2
Molecular Weight	243.49 g/mol
Synonyms	2-Bromo-3-chloro-1,8-naphthyridine; 3-Chloro-2-bromo-1,8-naphthyridine; 1,8-Naphthyridine, 2-bromo-3-chloro-; 2-Bromo-3-chloro-[1,8]naphthyridine; Bromochloro-1,8-naphthyridine
EINECS	Contact for details

Quality Control

Our 2-Bromo-3-Chloro-1,8-Naphthyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.