Description

L-Threonine, n-(Trifluoroacetyl)-, Trimethylsilyl Ester, Trifluoroacet Ate (Ester) is a high-purity, specialty protected amino acid derivative designed for advanced synthetic chemistry. This compound is critical for researchers and manufacturers requiring precise molecular building blocks for peptide synthesis and pharmaceutical intermediate development. It is primarily utilized in the research and production of novel active pharmaceutical ingredients (APIs), complex organic molecules, and fine chemicals.

Application

• Pharmaceutical Intermediate: A key protected building block in the multi-step synthesis of complex peptides and therapeutic compounds.
• Organic Synthesis Reagent: Used in research laboratories for the introduction of threonine moieties under controlled conditions, leveraging the trimethylsilyl and trifluoroacetyl protecting groups.
• Peptide Chemistry: Facilitates the controlled coupling and deprotection sequences essential for solid-phase and solution-phase peptide synthesis.
• Bioconjugation & Labeling: Serves as a precursor for creating modified amino acids used in bioconjugation strategies for drug delivery systems or diagnostic agents.
• Process Development: Employed in scaling up synthetic routes for candidate drugs during preclinical and process chemistry stages.
• Academic & Industrial R&D: A valuable tool for chemists in universities and corporate R&D departments exploring new synthetic methodologies and bioactive molecules.

Basic Information

Product Name	L-Threonine, n-(Trifluoroacetyl)-, Trimethylsilyl Ester, Trifluoroacet Ate (Ester)
CAS No.	52558-90-4
Molecular Formula	C11H16F6NO4Si
Molecular Weight	368.33 g/mol
Synonyms	N-(Trifluoroacetyl)-L-threonine trimethylsilyl ester; L-Threonine, N-trifluoroacetyl-, trimethylsilyl ester; Trimethylsilyl N-trifluoroacetyl-L-threoninate; (2S,3R)-2-[(Trifluoroacetyl)amino]-3-[(trimethylsilyl)oxy]butanoic acid; N-TFA-L-threonine-OTMS; Threonine derivative (TFA, OTMS); Protected L-threonine silyl ester
EINECS	Contact for details

Quality Control

Our production of L-Threonine, n-(Trifluoroacetyl)-, Trimethylsilyl Ester, Trifluoroacet Ate (Ester) adheres to stringent in-process controls to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and MS to confirm identity and purity. Certificates of Analysis (COA) detailing all relevant specifications are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.