Description

N,o-Bis(Trifluoroacetyl)-L-Serine Trimethylsilyl Ester is a high-purity, protected derivative of the amino acid L-serine, specifically designed for advanced synthetic applications. This compound is critical for researchers and manufacturers requiring precise, moisture-sensitive intermediates in complex organic synthesis. It is primarily utilized in the pharmaceutical and biotechnology sectors for the production of peptides, chiral building blocks, and other fine chemicals where protecting group chemistry is essential.

Application

• Peptide Synthesis: Serves as a key protected serine derivative in solid-phase and solution-phase peptide synthesis, preventing unwanted side reactions.
• Chiral Intermediate: Used in the synthesis of complex chiral molecules for pharmaceutical active ingredients (APIs) and agrochemicals.
• Bioconjugation Reagent: Acts as a precursor for modifying biomolecules, useful in drug delivery systems and diagnostic agent development.
• Organic Synthesis Building Block: Employed in academic and industrial research for constructing complex heterocycles and natural product analogs.
• Protecting Group Chemistry: The trifluoroacetyl and trimethylsilyl groups provide orthogonal protection strategies in multi-step synthetic sequences.
• Analytical Reference Standard: Used as a high-purity standard in analytical methods like HPLC and LC-MS for quality control in related chemical processes.

Basic Information

Item	Detail
Product Name	N,o-Bis(Trifluoroacetyl)-L-Serine Trimethylsilyl Ester
CAS No.	52558-89-1
Molecular Formula	C11H14F6NO5Si
Molecular Weight	382.22 g/mol
Synonyms	L-Serine, N,o-bis(trifluoroacetyl)-, trimethylsilyl ester; N,O-Bis(trifluoroacetyl)-L-serine trimethylsilyl ester; Trimethylsilyl N,O-bis(trifluoroacetyl)-L-serinate; (S)-2-((Trimethylsilyl)oxy)-3-((2,2,2-trifluoroacetyl)amino)propanoic acid 2,2,2-trifluoroacetic anhydride; Serine derivative, TFA protected; TFA-L-Ser-OTMS; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our N,o-Bis(Trifluoroacetyl)-L-Serine Trimethylsilyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the exacting standards required for pharmaceutical and research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and specific tests is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent hydrolysis. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.