Description

1-(Trifluoroacetyl)-L-Proline Trimethylsilyl Ester is a high-purity, protected amino acid derivative designed for advanced synthetic applications. This compound is a critical building block for the synthesis of complex peptides and peptidomimetics, offering enhanced reactivity and stability during coupling reactions. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, process development, and the production of active pharmaceutical ingredients (APIs).

Application

• Peptide Synthesis: A key protected intermediate for the solid-phase and solution-phase synthesis of proline-containing peptides.
• Pharmaceutical Research: Used in the discovery and development of novel therapeutic agents, particularly protease inhibitors and receptor ligands.
• Process Chemistry: Serves as a crucial reagent in the scalable manufacturing of peptide-based Active Pharmaceutical Ingredients (APIs).
• Bioconjugation: Facilitates the site-specific modification of peptides and proteins for diagnostic and therapeutic applications.
• Chemical Biology: Employed in the synthesis of probes and tools for studying enzyme mechanisms and protein-protein interactions.
• Material Science: A precursor for creating specialized polymers and coatings with unique surface properties.

Basic Information

Product Name	1-(Trifluoroacetyl)-L-Proline Trimethylsilyl Ester
CAS No.	52558-87-9
Molecular Formula	C10H14F3NO3Si
Molecular Weight	281.30 g/mol
Synonyms	L-Proline, 1-[(trifluoroacetyl)-, trimethylsilyl ester; (S)-1-(Trifluoroacetyl)pyrrolidine-2-carboxylic acid trimethylsilyl ester; N-(Trifluoroacetyl)-L-proline trimethylsilyl ester; TFA-L-Pro-OTMS; Trimethylsilyl 1-(trifluoroacetyl)-L-prolinate; 1-(Trifluoroacetyl)-L-proline TMS ester
EINECS	Contact for details

Quality Control

Every batch of 1-(Trifluoroacetyl)-L-Proline Trimethylsilyl Ester is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure compliance with exacting research and pharmaceutical-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.