Description

Nα,1-Bis(Trifluoroacetyl)-L-Tryptophan Trimethylsilyl Ester is a key protected derivative of the essential amino acid L-tryptophan, designed for advanced synthetic applications. This compound is crucial for researchers and manufacturers requiring high-purity, reactive intermediates for peptide synthesis and pharmaceutical development. It is primarily utilized in the production of complex peptides, active pharmaceutical ingredients (APIs), and as a building block in medicinal chemistry research.

Application

• Peptide Synthesis Intermediate: Serves as a protected tryptophan derivative in solid-phase and solution-phase peptide synthesis, preventing unwanted side reactions.
• Pharmaceutical Research & Development: Used as a key building block in the synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and the development of peptide-based therapeutics.
• Bioconjugation: Acts as a reagent for modifying peptides and proteins due to its reactive ester and protecting groups.
• Analytical Reference Standard: Utilized as a high-purity standard in chromatographic analysis (HPLC, LC-MS) for quality control in pharmaceutical manufacturing.
• Biochemical Research: Applied in studies involving enzyme substrates, inhibitors, and probes related to tryptophan metabolism.

Basic Information

Product Name	Nα,1-Bis(Trifluoroacetyl)-L-Tryptophan Trimethylsilyl Ester
CAS No.	52558-86-8
Molecular Formula	C20H20F6N2O4Si
Molecular Weight	494.47 g/mol
Synonyms	Nα,N1-Bis(trifluoroacetyl)-L-tryptophan trimethylsilyl ester; L-Tryptophan, Nα,1-bis(trifluoroacetyl)-, trimethylsilyl ester; Nα,N1-Di(trifluoroacetyl)-L-tryptophan trimethylsilyl ester; TFA-Tryptophan(TFA)-OTMS; Nα,N1-Bis(trifluoroacetyl)tryptophan trimethylsilyl ester; (S)-2,2,2-Trifluoro-N-(2,2,2-trifluoro-1-oxo-1-((trimethylsilyl)oxy)-3-(1H-indol-3-yl)propan-2-yl)acetamide; Protected L-Tryptophan derivative; Tryptophan bis-TFA TMS ester
EINECS	Contact for details

Quality Control

Our Nα,1-Bis(Trifluoroacetyl)-L-Tryptophan Trimethylsilyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality system is designed to meet the rigorous standards required for chemical intermediates in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area %)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.