Description

N,o-Bis(Trifluoroacetyl)-L-Tyrosine Trimethylsilyl Ester is a key protected derivative of the amino acid L-tyrosine, specifically designed for advanced analytical and synthetic chemistry. This compound is critically important for enabling precise analysis and controlled derivatization in sensitive applications where volatility and detection sensitivity are paramount. It is primarily utilized by research institutions, pharmaceutical developers, and analytical laboratories engaged in gas chromatography-mass spectrometry (GC-MS) and proteomics research.

Application

• GC-MS Derivatization Agent: Essential for the analysis of amino acids, peptides, and related metabolites by enhancing their volatility and thermal stability for accurate gas chromatographic separation and mass spectrometric detection.
• Proteomics and Metabolomics Research: Used in sample preparation workflows for the identification and quantification of tyrosine-containing biomolecules in complex biological matrices.
• Pharmaceutical Intermediate: Serves as a protected building block in the multi-step synthesis of complex peptides, peptidomimetics, and other bioactive molecules requiring specific tyrosine modification.
• Isotope Labeling Studies: Employed in the synthesis of stable isotope-labeled internal standards for use in quantitative mass spectrometry, ensuring high accuracy in analytical measurements.
• Analytical Reference Standard: Provides a high-purity benchmark for method development, validation, and quality control in analytical laboratories.

Basic Information

Product Name	N,o-Bis(Trifluoroacetyl)-L-Tyrosine Trimethylsilyl Ester
CAS No.	52558-85-7
Molecular Formula	C18H21F6NO5Si
Molecular Weight	473.45 g/mol
Synonyms	L-Tyrosine, N,o-bis(trifluoroacetyl)-, trimethylsilyl ester; N,O-Bis(trifluoroacetyl)-L-tyrosine TMS ester; TFA-Tyr(TFA)-OTMS; (2S)-2-[(Trifluoroacetyl)amino]-3-[4-[(trimethylsilyl)oxy]phenyl]propanoic acid, 2,2,2-trifluoroacetate; Tyrosine derivative, TFA2-TMS; N,O-Bis-TFA-L-tyrosine trimethylsilyl ester; L-Tyrosine TFA2 TMS ester
EINECS	Contact for details

Quality Control

Our N,o-Bis(Trifluoroacetyl)-L-Tyrosine Trimethylsilyl Ester is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure batch-to-batch consistency and high purity suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to stringent in-house quality standards aligned with best practices for research-grade fine chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.