Description

n-(Trifluoroacetyl)-L-Phenylalanine Trimethylsilyl Ester is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound is a critical building block for peptide chemists, offering a reactive handle for the controlled introduction of the L-phenylalanine moiety while protecting sensitive functional groups. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and other bioactive molecules requiring sophisticated synthetic strategies.

Application

• Peptide Synthesis: Serves as a key protected intermediate in solid-phase and solution-phase peptide synthesis (SPPS), particularly for complex sequences.
• Pharmaceutical Research: Used in the research and development of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation: Acts as a precursor for creating labeled peptides or peptide conjugates for diagnostic and therapeutic applications.
• Chemical Biology: Employed in the synthesis of peptide probes and tools for studying protein-protein interactions and enzyme function.
• Process Development: Utilized in scaling up synthetic routes for peptide drugs, ensuring reproducibility and high yield.
• Academic Research: A valuable reagent for university and institutional labs exploring new synthetic methodologies and peptide chemistry.

Basic Information

Item	Details
Product Name	n-(Trifluoroacetyl)-L-Phenylalanine Trimethylsilyl Ester
CAS No.	52558-84-6
Molecular Formula	C₁₄H₁₈F₃NO₃Si
Molecular Weight	333.38 g/mol
Synonyms	N-(Trifluoroacetyl)-L-phenylalanine trimethylsilyl ester; L-Phenylalanine, N-(trifluoroacetyl)-, trimethylsilyl ester; (S)-2-((Trimethylsilyl)oxy)-1-(2,2,2-trifluoro-N-phenethylacetamido)-2-phenylethane; N-Trifluoroacetyl-L-phenylalanine TMS ester; N-TFA-L-Phe-OTMS; TFA-Phe-OTMS; N-(Trifluoroacetyl)phenylalanine trimethylsilyl ester; Fmoc-Phe(Trt)-OH (related protected form)
EINECS	Contact for details

Quality Control

Every batch of n-(Trifluoroacetyl)-L-Phenylalanine Trimethylsilyl Ester is manufactured under strict quality management systems. We guarantee high chemical purity and consistency, with comprehensive analytical testing performed to confirm identity, potency, and impurity profiles. A Certificate of Analysis (COA) detailing specific results for each lot is provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure containers are sealed immediately after use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.