Description

n-(Trifluoroacetyl)-L-Leucine Trimethylsilyl Ester is a high-purity, protected amino acid derivative used as a critical building block in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring precise control over stereochemistry and functional group manipulation. It is primarily utilized in the development of pharmaceuticals, peptides, and complex bioactive molecules where the integrity of the L-leucine moiety must be preserved.

Application

• Peptide Synthesis: Serves as a protected L-leucine derivative for solid-phase and solution-phase peptide synthesis, preventing unwanted side reactions.
• Pharmaceutical Intermediates: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those targeting metabolic and neurological pathways.
• Proteomics Research: Used in chemical biology for labeling, cross-linking, or modifying peptides and proteins in structural and functional studies.
• Chiral Auxiliary: Exploits the chiral center of L-leucine for asymmetric synthesis to create enantiomerically pure compounds.
• Mass Spectrometry Standards: Can be utilized as a derivatization agent or a reference standard in analytical methods like GC-MS or LC-MS for amino acid analysis.
• Bioconjugation: Facilitates the attachment of peptides or drug molecules to other entities like polymers, surfaces, or biomarkers.

Basic Information

Product Name	n-(Trifluoroacetyl)-L-Leucine Trimethylsilyl Ester
CAS No.	52558-82-4
Molecular Formula	C11H20F3NO3Si
Molecular Weight	299.36 g/mol
Synonyms	L-Leucine, N-[(trifluoroacetyl)-, trimethylsilyl ester; N-(Trifluoroacetyl)-L-leucine trimethylsilyl ester; N-Trifluoroacetyl-L-leucine TMS ester; TFA-L-Leu-OTMS; (S)-2-((Trimethylsilyl)oxy)-4-methyl-1-(2,2,2-trifluoroacetamido)pent-1-ene; Trimethylsilyl N-(trifluoroacetyl)-L-leucinate; N-[(Trifluoroacetyl)-L-leucine] trimethylsilyl ester
EINECS	Contact for details

Quality Control

Our n-(Trifluoroacetyl)-L-Leucine Trimethylsilyl Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research and production applications. Each lot undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling. Certificates of Analysis (COA) detailing identity, assay, and purity are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (L-Isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.