Description

n-(Trifluoroacetyl)-L-Alanine Trimethylsilyl Ester is a high-purity, protected amino acid derivative designed for advanced synthetic applications. This compound is a critical building block in peptide synthesis and pharmaceutical research, offering enhanced reactivity and stability for complex molecular construction. It is primarily utilized by research institutions, pharmaceutical developers, and fine chemical manufacturers engaged in the production of novel peptides, active pharmaceutical ingredients (APIs), and other sophisticated organic molecules.

Application

• Peptide Synthesis: A key protected intermediate for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics.
• Pharmaceutical Intermediates: Serves as a crucial building block in the research and development of new therapeutic agents and active pharmaceutical ingredients (APIs).
• Proteomics & Biochemistry Research: Used in the study of protein structure, function, and in the preparation of labeled amino acids for analytical purposes.
• Organic Synthesis: Acts as a versatile reagent for introducing the L-alanine moiety with a protected amine group into complex organic molecules.
• Chiral Auxiliary & Catalyst Development: Employed in the development of chiral catalysts and auxiliaries due to its defined stereochemistry.

Basic Information

Product Name	n-(Trifluoroacetyl)-L-Alanine Trimethylsilyl Ester
CAS No.	52558-80-2
Molecular Formula	C8H14F3NO3Si
Molecular Weight	257.28 g/mol
Synonyms	L-Alanine, N-[(trifluoroacetyl)-, trimethylsilyl ester; N-(Trifluoroacetyl)-L-alanine trimethylsilyl ester; Trimethylsilyl N-(trifluoroacetyl)-L-alaninate; TFA-L-Ala-OTMS; (S)-2-((Trimethylsilyl)oxy)-N-(2,2,2-trifluoroacetyl)propanamide; Alanine, N-trifluoroacetyl-, trimethylsilyl ester, L-; N-Trifluoroacetyl-L-alanine TMS ester
EINECS	Contact for details

Quality Control

Our n-(Trifluoroacetyl)-L-Alanine Trimethylsilyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and specific test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.