Description

Glycine, n-(Trifluoroacetyl)-, Trimethylsilyl Ester is a specialized organosilicon and fluorinated derivative of the amino acid glycine, designed for advanced synthetic applications. This compound is a crucial reagent in organic synthesis, valued for its dual functionality as a protected amino acid derivative and a versatile silylating agent. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of peptides, modified amino acids, and complex organic molecules.

Application

• Peptide Synthesis Intermediate: Serves as a key building block for introducing glycine units with orthogonal protecting groups in solid-phase and solution-phase peptide synthesis.
• Amino Acid Derivatization: Used for the protection and silylation of amino acids in analytical chemistry and synthetic routes to create novel amino acid analogs.
• Pharmaceutical Research: Employed in the research and development of active pharmaceutical ingredients (APIs) and prodrugs, particularly those requiring fluorinated motifs.
• Agrochemical Synthesis: Acts as an intermediate in the production of specialized herbicides, pesticides, and plant growth regulators.
• Chemical Proteomics & Labeling: Utilized in biochemical research for modifying proteins or peptides to study structure, function, or interaction.
• Material Science Precursor: Can be used in the synthesis of silicon-containing polymers or hybrid organic-inorganic materials.

Basic Information

Product Name	Glycine, n-(Trifluoroacetyl)-, Trimethylsilyl Ester
CAS No.	52558-79-9
Molecular Formula	C7H12F3NO3Si
Molecular Weight	243.26 g/mol
Synonyms	N-(Trifluoroacetyl)glycine trimethylsilyl ester; Trimethylsilyl N-trifluoroacetylglycinate; N-Trifluoroacetylglycine TMS ester; Glycine, N-(trifluoroacetyl)-, trimethylsilyl ester; TFA-Gly-OTMS; (Trimethylsilyl) 2-[(trifluoroacetyl)amino]acetate; 2-[(Trifluoroacetyl)amino]acetic acid trimethylsilyl ester
EINECS	Contact for details

Quality Control

Our Glycine, n-(Trifluoroacetyl)-, Trimethylsilyl Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chromatography (HPLC, GC) and spectroscopy (NMR, IR), to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP-compliant production for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture ingress and decomposition. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.