Description

3',5',7-Tribromo-5-(Hydroxymethyl)Spiro[Benzofuran-2(3H),1'-[2,5]Cyclohexadien]-4'-One is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic and brominated structure. This compound matters for its critical role in the synthesis of novel active pharmaceutical ingredients (APIs), where it serves as a key building block to introduce specific bromine-substituted motifs. Pharmaceutical R&D and fine chemical synthesis companies need this material to develop new therapeutic agents, particularly in areas requiring halogenated molecular architectures for enhanced bioactivity and binding specificity.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of novel Active Pharmaceutical Ingredients (APIs) and drug candidates.
• Organic Synthesis Reagent: Used in research and development for constructing complex spirocyclic and brominated organic molecules.
• Chemical Biology Probe Development: Serves as a precursor for synthesizing molecular probes used in target identification and validation studies.
• Agrochemical Research: Potential intermediate in the development of new crop protection agents and pesticides.
• Material Science Research: Investigated as a monomer or precursor for specialty polymers and advanced organic materials.

Basic Information

Product Name	3',5',7-Tribromo-5-(Hydroxymethyl)Spiro[Benzofuran-2(3H),1'-[2,5]Cyclohexadien]-4'-One
CAS No.	52498-93-8
Molecular Formula	C14H9Br3O3
Molecular Weight	464.93 g/mol
Synonyms	5-(Hydroxymethyl)-3',5',7-tribromospiro[benzofuran-2(3H),1'-[2,5]cyclohexadien]-4'-one; Tribromospirobenzofurandione derivative; 3',5',7-Tribromo-5-(hydroxymethyl)spiro[benzofuran-2(3H),1'-[2,5]cyclohexadien]-4'-one; CAS 52498-93-8; Spiro[benzofuran-2(3H),1'-[2,5]cyclohexadien]-4'-one, 3',5',7-tribromo-5-(hydroxymethyl)-; 5-(Hydroxymethyl)-3',5',7-tribromospiro[benzofuran-2(3H),1'-[2,5]cyclohexadien]-4'-one
EINECS	Contact for details

Quality Control

Our 3',5',7-Tribromo-5-(Hydroxymethyl)Spiro[Benzofuran-2(3H),1'-[2,5]Cyclohexadien]-4'-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical R&D. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and Mass Spectrometry. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to minimize moisture exposure. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.