Description

Adrenaline Sulfate CAS NO 52455-32-0 is the sulfate salt form of the essential hormone and neurotransmitter epinephrine, a critical catecholamine. This high-purity active pharmaceutical ingredient (API) is fundamental for its potent vasoconstrictive, bronchodilatory, and cardiac stimulant properties. It is primarily required by pharmaceutical manufacturers for the formulation of emergency medications, including injectable solutions for anaphylaxis, cardiac arrest, and severe asthma, as well as in topical hemostatic agents.

Application

• Emergency Injectable Formulations: Critical component in auto-injectors and ampoules for the treatment of anaphylactic shock, severe allergic reactions, and cardiac arrest.
• Topical Hemostatic Agents: Used in solutions and soaked swabs to control capillary bleeding in surgical and dental procedures due to its potent vasoconstrictive action.
• Ophthalmic Solutions: Employed in eye drops for managing open-angle glaucoma and for achieving mydriasis (pupil dilation) during ophthalmic surgery.
• Bronchodilator Medications: Formulated in inhalers and nebulizer solutions for the acute relief of bronchospasm in conditions like asthma and COPD.
• Local Anesthetic Adjuvant: Added to local anesthetics (e.g., in dentistry) to prolong their effect and reduce systemic absorption by causing local vasoconstriction.
• Research & Diagnostic Use: Serves as a standard and reagent in biochemical research, clinical diagnostics, and pharmacological studies targeting adrenergic receptors.

Basic Information

Product Name	Adrenaline Sulfate
CAS No.	52455-32-0
Molecular Formula	C9H13NO3 • 1/2H2SO4
Molecular Weight	368.38 g/mol (for the sulfate salt)
Synonyms	Epinephrine Sulfate; (-)-Epinephrine Sulfate; L-Epinephrine Sulfate; Adrenaline Sulphate; 1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol Sulfate; 4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol Sulfate; Adrenalin Sulfate; Suprarenin Sulfate
EINECS	Contact for details

Quality Control

Our Adrenaline Sulfate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing to ensure it meets stringent pharmacopeial standards, including identity, purity, potency, and limits for specific impurities. A Certificate of Analysis (COA) detailing results against specifications such as USP, EP, or BP monographs is provided with every shipment to guarantee traceability and compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This product is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). The container must be kept tightly sealed in a dry environment to minimize exposure to air and moisture.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Specific Rotation	-50.0° to -53.5° (c = 2 in water)
pH (1% Solution)	2.8 - 4.0
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.