Description

Pyridine, 5-(Chloromethyl)-2-Methyl- (6Ci,9Ci) is a versatile halogenated pyridine derivative with a reactive chloromethyl group, serving as a critical building block in advanced organic synthesis. Its unique bifunctional structure, combining a pyridine ring with a reactive alkyl halide moiety, makes it an invaluable intermediate for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to develop active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing functionalized pyridine cores.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the chloromethyl group enables further derivatization.
• Ligand and Catalyst Development: Serves as a starting material for creating novel nitrogen-containing ligands for transition metal catalysis.
• Material Science Monomer: Employed in the synthesis of functional polymers and advanced materials, including liquid crystals and conductive polymers.
• Chemical Research & Development: A valuable reagent in medicinal chemistry and process R&D for introducing the 2-methyl-5-chloromethylpyridine scaffold.
• Cross-Coupling Reactions: Acts as a substrate in various palladium-catalyzed cross-coupling reactions to form more complex biaryl systems.

Basic Information

Product Name	Pyridine, 5-(Chloromethyl)-2-Methyl- (6Ci,9Ci)
CAS No.	52426-66-1
Molecular Formula	C7H8ClN
Molecular Weight	141.60 g/mol
Synonyms	2-Methyl-5-(chloromethyl)pyridine; 5-(Chloromethyl)-2-picoline; 2-Picoline, 5-(chloromethyl)-; 2-Methyl-5-chloromethylpyridine; 5-Chloromethyl-2-methylpyridine; 2-Methyl-5-pyridylmethyl chloride; (6-Chloro-2-methylpyridin-3-yl)methanol (tautomer); 3-(Chloromethyl)-6-methylpyridine
EINECS	Contact for details

Quality Control

Our Pyridine, 5-(Chloromethyl)-2-Methyl- (6Ci,9Ci) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific project requirements, from research to commercial scale.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C/59-77°F). Keep away from strong bases and incompatible materials. Due to the reactive chloromethyl group, ensure containers are sealed under an inert atmosphere if specified for long-term storage to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Chloride Content	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.