Description

(R)-(+)-2,2-Dimethyl-1,3-Dioxolane-4-Carboxylic Acid Methyl Ester is a high-value chiral building block and protected form of glyceric acid, essential for the stereoselective synthesis of complex molecules. Its primary value lies in providing a versatile, enantiomerically pure scaffold for constructing biologically active compounds, ensuring high optical purity in the final products. This intermediate is critically needed by pharmaceutical, agrochemical, and fine chemical R&D and manufacturing sectors for applications ranging from antiviral and antibiotic development to advanced material science.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of antiviral agents, antibiotics (e.g., β-lactams), and other active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Serves as a precursor for specialty chemicals, flavors, fragrances, and advanced polymers requiring specific chirality.
• Glycidate Chemistry: Acts as a protected glycidate equivalent in ring-opening and nucleophilic addition reactions to introduce functionalized three-carbon chains.
• Asymmetric Synthesis: Employed in catalytic asymmetric transformations and as a starting material for chiral ligands and catalysts.
• Biochemical Research: Utilized in the study of enzyme mechanisms and the synthesis of labeled compounds for metabolic pathway analysis.

Basic Information

Product Name	(R)-(+)-2,2-Dimethyl-1,3-Dioxolane-4-Carboxylic Acid Methyl Ester
CAS No.	52373-72-5
Molecular Formula	C7H12O4
Molecular Weight	160.17 g/mol
Synonyms	(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic acid methyl ester; Methyl (R)-(+)-2,2-dimethyl-1,3-dioxolane-4-carboxylate; (R)-(-)-2,3-O-Isopropylidene-D-glyceric acid methyl ester; (R)-(-)-2,3-O-Isopropylideneglyceric acid methyl ester; (R)-Methyl 2,2-dimethyl-1,3-dioxolane-4-carboxylate; (4R)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic acid methyl ester; D-Glyceric acid, 2,3-O-(1-methylethylidene)-, methyl ester, (R)-; (R)-O-Isopropylidene glycerate methyl ester
EINECS	257-858-7

Quality Control

Our (R)-(+)-2,2-Dimethyl-1,3-Dioxolane-4-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure compliance with high-purity standards for chiral intermediates. Key parameters such as enantiomeric excess (ee), chemical purity, and identity are verified. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Specific Rotation [α]20/D	-8.0° to -10.0° (c=1 in CHCl3)
Refractive Index n20/D	1.420 - 1.425
Density (20°C)	1.10 - 1.15 g/mL
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.