Description

Nimustine Hydrochloride CAS NO 52208-23-8 is a potent nitrosourea-based alkylating agent used in antineoplastic therapy. This compound is critical for its role in disrupting DNA replication and transcription in rapidly dividing cells. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of chemotherapeutic treatments for specific cancers, including brain tumors and leukemia.

Application

• Oncological Pharmaceutical Manufacturing: As an active pharmaceutical ingredient (API) in injectable formulations for chemotherapy.
• Clinical Cancer Research: For in-vitro and in-vivo studies investigating the efficacy and mechanisms of nitrosourea compounds.
• Reference Standard Production: Serves as a high-purity analytical standard for quality control testing in pharmaceutical labs.
• Drug Discovery & Development: Used in preclinical research for synthesizing novel derivatives or combination therapies.
• Hospital Pharmacy Compounding: For specialized preparation of chemotherapeutic regimens in controlled settings (subject to regional regulations).

Basic Information

Product Name	Nimustine Hydrochloride
CAS No.	52208-23-8
Molecular Formula	C9H13ClN6O2 • HCl
Molecular Weight	309.15 g/mol
Synonyms	ACNU; 1-(4-Amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea Hydrochloride; Nidran; Nimustine HCl; 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitrosourea Hydrochloride; 1-(2-Chloroethyl)-3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-nitrosourea Hydrochloride
EINECS	Contact for details

Quality Control

Our Nimustine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical research and development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.