Description

Estramustine Sodium Phosphate is a water-soluble nitrogen mustard derivative of estradiol-17β-phosphate, designed for targeted therapeutic applications. This compound is significant for its dual-action mechanism, combining hormonal and cytotoxic alkylating properties. It is primarily required by the pharmaceutical industry for research and development in oncology, specifically for the treatment of hormone-refractory prostate cancer.

Application

• Pharmaceutical Active Ingredient (API): Primary use as a chemotherapeutic agent for advanced prostate cancer.
• Oncology Research: A key compound in preclinical and clinical studies investigating hormone-refractory cancer treatments.
• Drug Delivery Studies: Used in research on targeted drug delivery systems due to its steroid-linked structure.
• Biochemical Research: Serves as a tool compound for studying the mechanisms of estramustine-binding proteins (EMBPs) and microtubule assembly inhibition.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for drug testing and validation.
• Formulation Development: Used in the development of injectable pharmaceutical formulations.

Basic Information

Product Name	Estramustine Sodium Phosphate
CAS No.	52205-73-9
Molecular Formula	C23H30Cl2NNa2O6P
Molecular Weight	564.34 g/mol
Synonyms	Estramustine Phosphate Sodium; Estracyt®; Emcyt; Estramustine Disodium Phosphate; NSC-89199; Ro 21-8837/001; 3-O-[Bis(2-chloroethyl)carbamoyl]-17β-estradiol 17-(dihydrogen phosphate) disodium salt; Estradiol 3-[N,N-bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate) disodium salt
EINECS	Contact for details

Quality Control

Our Estramustine Sodium Phosphate is manufactured under strict quality management systems. Each batch is tested to meet high-purity standards suitable for pharmaceutical research and development. Comprehensive testing includes identification, assay, impurity profiling, and residual solvent analysis. A Certificate of Analysis (COA) documenting all test results is provided with every shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.