Description

n-[1-(Trifluoroacetyl)-L-Prolyl]-L-Isoleucine Methyl Ester is a high-purity, non-natural dipeptide derivative designed for advanced chemical synthesis and research. This compound serves as a critical chiral building block and intermediate in the development of complex bioactive molecules. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in peptide chemistry and medicinal chemistry projects.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of peptide-based drug candidates and protease inhibitors.
• Research Chemical: Used in academic and industrial R&D for studying peptide coupling reactions, stereochemistry, and structure-activity relationships (SAR).
• Fine Chemical Synthesis: Serves as a protected dipeptide precursor for constructing more complex polypeptides and custom amino acid derivatives.
• Bioconjugation: Potential use in the preparation of labeled peptides or peptide conjugates for diagnostic and biochemical applications.
• Chemical Biology Tool: Employed in the development of chemical probes to study enzyme function and biological pathways.

Basic Information

Product Name	n-[1-(Trifluoroacetyl)-L-Prolyl]-L-Isoleucine Methyl Ester
CAS No.	52183-94-5
Molecular Formula	C17H25F3N2O5
Molecular Weight	394.39 g/mol
Synonyms	L-Isoleucine, N-[1-(trifluoroacetyl)-L-prolyl]-, methyl ester; Methyl N-[1-(trifluoroacetyl)-L-prolyl]-L-isoleucinate; Tfa-L-Pro-L-Ile-OMe; (S)-Methyl 2-((S)-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxamido)-3-methylpentanoate; N-(1-Trifluoroacetyl-L-prolyl)-L-isoleucine methyl ester; Trifluoroacetyl-L-prolyl-L-isoleucine methyl ester; TFA-Pro-Ile-OMe
EINECS	Contact for details

Quality Control

Our n-[1-(Trifluoroacetyl)-L-Prolyl]-L-Isoleucine Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing purity, identity, and specific test results are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.